WebThe enediyne antitumor antibiotic C-1027 chromoprotein is produced by Streptomyces globisporus. The biosynthesis of the (S)-3-chloro-4,5-dihydroxy-β-phenylalanine moiety … WebThese enediyne antibiotics are one of the most potent antitumoral agents and have unique molecular architecture, intricate mechanisms of action, and remarkable biological activities, ... Each chromoprotein generates a unique set of cleavage products of histone H1. The kedarcidin apoprotein appears to be less specific than the kedaracidin ...
A convergent total synthesis of the kedarcidin chromophore: 20
WebThe first example of these coupling reactions was reported in 2000 by Myers and Goldberg. 191 In the context of a study on the synthesis of the core structure of the chromoprotein enediyne antibiotic, kedarcidin, 192 they found that the Pd(PPh 3) 4 /CuI-catalyzed reaction of dibromoalkene 371 with monoprotected diyne 372 in Et 2 O in the ... Webmembered enediyne compound produced by S. carzinosta-ticus, is the most studied among the chromoprotein type enediyne antibiotics. It consists of a 1:1 complex of a nonpeptide chromophore (NCS chromophore) and a pep-tide apoprotein (Apo-NCS). The NCS chromophore con-sists of three different moieties: a nine-membered enediyne the highway series in order
Biosynthesis of the β-amino acid moiety of the enediyne …
WebSep 1, 2016 · The chromoprotein family of enediyne antitumor antibiotics includes some of the most cytotoxic natural products known to date.13, 14 As exemplified by C-1027,15, 16, 17, 18 the chromoprotein is a noncovalent protein-small molecule complex consisting of an apo-protein (CagA) and an enediyne chromophore (C-1027) (Fig. 1). WebAug 16, 2002 · The enediynes exemplify nature's ingenuity. We have cloned and characterized the biosynthetic locus coding for perhaps the most notorious member of … WebRong-guang Shao, Yong-su Zhen, in Recent Advances in Cancer Research and Therapy, 2012. 7.2.3 mAb–Enediyne Drugs. The enediyne antitumor antibiotics with highly … the highway stalker