WebAzido-PEG4-Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH. Purity: >98% Clinical Data:No Development Reported Size: 1 mg, 5 mg, 10 mg Bi-Mc-VC-PAB-MMAE Cat. No.: HY-141833 Bi-Mc-VC-PAB-MMAE ... WebTrastuzumab deruxtecan (T-DXd) is an ADC composed of an anti-HER2 antibody, a cleavable tetrapeptide-based linker, and a cytotoxic topoisomerase I inhibitor approved …
Drug-Linker Conjugates for ADC - MedchemExpress.com
WebApr 12, 2024 · DXd is a more potent analog of SN-38, the active metabolite of the systemic chemotherapy drug irinotecan. A tetrapeptide-based linker connects DXd to an antibody that targets HER2, a protein sometimes … WebCutler Hammer MDSX50 Insulated Case Circuit Breaker. Family Magnum DS; Type MDSX; 3 Pole; 3 Phase; 5000 Amp; 200kA@508V AIC; Bolt-On Mounting. Eaton's Magnum DS … haydn horn concerto
美迪西抗体药物偶联物(ADC)研发服务平台 - 知乎
WebMar 9, 2024 · As we knew that a PSAR length of 12 sarcosine residues was an optimal value for the monomethyl auristatin E (MMAE) payload and that exatecan is slightly less hydrophobic than MMAE (logP exatecan = 1.67–3.29 and logP MMAE = 3.44–4.61 as predicted in silico ), we selected a length of 10 sarcosine residues. WebMar 10, 2024 · 2024年,T-DXd(DS-8201,Enhertu)成为第二个获批的新型HER2 ADC药物,它在难治性HER2+转移性乳腺癌患者中显示出显著的抗肿瘤活性。 ... 毒素MMAE是一种 ... WebExatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research. For research use only. We do not sell to patients. Exatecan Chemical Structure CAS No. : … haydn horn concerto #1