WebHere, we established mice with CMG2 only expressed in tumor endothelial cells (ECs) and determined the specific contribution of tumor stromal ECs to the toxin’s antitumor activity. Our results demonstrate that disruption of ERK signaling only within tumor ECs is sufficient to halt tumor growth. WebCapillary morphogenesis gene 2 (CMG2) is a type I mem-brane protein involved in the homeostasis of the extra- ... cleaved by the pro-protein convertase furin into a 63-kDa protein. PA63 has the capacity to oligomerize into heptameric or octameric rings, to which EF/LF can bind. The binding to

Juvenile hyaline fibromatosis - Wikipedia

WebThis condition is due to mutations in the anthrax toxin receptor-2 ( ANTXR2) gene. This gene is also known as capillary morphogenesis protein-2. This gene is located on the long arm of chromosome 4 (4q21.21). Management [ edit] There is no presently known curative treatment for this condition. [citation needed] Management is supportive WebMar 20, 2024 · HFS is a rare autosomal recessive disease without ethnic predilection caused by loss-of-function mutations in anthrax toxin receptor 2 gene (ANTXR2) (MIM #608041), also called capillary morphogenesis gene 2 (CMG2) at 4q21 (Dowling et al., 2003). It is expressed in all tissues except the brain and encodes a 55 kDa type I … say it sign it letters

Imaging of anthrax intoxication in mice reveals shared and …

WebJan 14, 2013 · CMG2 is a transmembrane protein that is induced during capillary morphogenesis and that binds laminin and collagen IV via a VWFA domain. The … WebFeb 23, 2024 · Capillary morphogenesis protein 2 (CMG2) was originally identified through its participation in capillary morphogenesis, and subsequently identified as the second … WebJan 3, 2024 · Since this activity requires the surface expression of the capillary morphogenesis protein-2 (CMG2) toxin receptor, genetic manipulation of CMG2 … scallop sandwich san diego